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Best of science compilation #1 - this weeks most interesting publications (in my opinion)

Wednesday 3 February 2021 at 15:41

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Edited by Greta Becker, Wednesday 3 February 2021 at 15:42

Best Of Science Compilation #1

This week’s most interesting publications (in my opinion):

(Epi)genetics:

EpiSigns: DNA Methylation Signatures in Mendelian Neurodevelopmental Disorders as a Diagnostic Link Between a Genotype and Phenotype -> https://www.sciencedirect.com/.../pii/S2589408020300193

Precision Therapies in Neurodevelopmental Disorders: Update on Gene Therapies -> https://www.sciencedirect.com/.../pii/S2589408020300181

Live-cell epigenome manipulation by synthetic histone acetylation catalyst system

-> https://www.pnas.org/content/118/4/e2019554118.short...

A scaffold lncRNA shapes the mitosis to meiosis switch -> https://www.nature.com/articles/s41467-021-21032-7

Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life -> https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246400

Cell/Molecular:

Colloidal stability of the living cell -> https://www.pnas.org/content/117/19/10113?cct=1736

(background info non quinary interactions (2018)) -> https://febs.onlinelibrary.wiley.com/.../1873-3468.13211

A novel spectroscopic window on conical intersections in biomolecules -> https://www.pnas.org/content/117/43/26553?cct=1736

Spatially resolved 3D metabolomic profiling in tissues -> https://advances.sciencemag.org/content/7/5/eabd0957

Molecular neuroscience and neuroendocrinology:

https://advances.sciencemag.org/content/7/5/eabd1707 ! Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases

https://advances.sciencemag.org/content/7/5/eabd9749 ! A 3D disease and regeneration model of peripheral nervous system–on–a–chip

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy -> https://elifesciences.org/articles/58744

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling -> https://www.nature.com/articles/s41598-018-25603-5...

Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte -> https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246116

Anti–Na+/K+-ATPase immunotherapy ameliorates α-synuclein pathology through activation of Na+/K+-ATPase α1–dependent autophagy ->

https://advances.sciencemag.org/content/7/5/eabc5062

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation ->

https://advances.sciencemag.org/content/7/5/eabe4497

Science and Culture: At the nexus of music and medicine, some see treatments for disease (#delirium)-> https://www.pnas.org/content/118/4/e2025750118

Senescence:

Gross ways to live long: Parasitic worms as an anti-inflammaging therapy? ->

https://elifesciences.org/articles/65180

Botany:

The impact of different Zinc (Zn) levels on growth and nutrient uptake of Basil (Ocimum basilicum L.) grown under salinity stress

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246493

Tags: protein folding, bbb, blood-brain barrier, alpha synuclein, amyloid beta, zinc, neuroscience botany, neuroendocrinology, parkinson's, dementia, alzheimer's, senescence, cell science, cells, cell, cytology, molecular biology, molecular, medicine, science, research

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