Best Of Science Compilation #1
This week’s most interesting publications (in my opinion):
(Epi)genetics:
EpiSigns: DNA Methylation Signatures in Mendelian Neurodevelopmental Disorders as a Diagnostic Link Between a Genotype and Phenotype -> https://www.sciencedirect.com/.../pii/S2589408020300193
Precision Therapies in Neurodevelopmental Disorders: Update on Gene Therapies -> https://www.sciencedirect.com/.../pii/S2589408020300181
Live-cell epigenome manipulation by synthetic histone acetylation catalyst system
A scaffold lncRNA shapes the mitosis to meiosis switch -> https://www.nature.com/articles/s41467-021-21032-7
Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life -> https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246400
Cell/Molecular:
Colloidal stability of the living cell -> https://www.pnas.org/content/117/19/10113?cct=1736
(background info non quinary interactions (2018)) -> https://febs.onlinelibrary.wiley.com/.../1873-3468.13211
A novel spectroscopic window on conical intersections in biomolecules -> https://www.pnas.org/content/117/43/26553?cct=1736
Spatially resolved 3D metabolomic profiling in tissues -> https://advances.sciencemag.org/content/7/5/eabd0957
Molecular neuroscience and neuroendocrinology:
https://advances.sciencemag.org/content/7/5/eabd1707 ! Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
https://advances.sciencemag.org/content/7/5/eabd9749 ! A 3D disease and regeneration model of peripheral nervous system–on–a–chip
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy -> https://elifesciences.org/articles/58744
Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling -> https://www.nature.com/articles/s41598-018-25603-5...
Quantifying the dose-dependent impact of intracellular amyloid beta in a mathematical model of calcium regulation in xenopus oocyte -> https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246116
Anti–Na+/K+-ATPase immunotherapy ameliorates α-synuclein pathology through activation of Na+/K+-ATPase α1–dependent autophagy ->
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation ->
Science and Culture: At the nexus of music and medicine, some see treatments for disease (#delirium)-> https://www.pnas.org/content/118/4/e2025750118
Senescence:
Gross ways to live long: Parasitic worms as an anti-inflammaging therapy? ->
Botany:
The impact of different Zinc (Zn) levels on growth and nutrient uptake of Basil (Ocimum basilicum L.) grown under salinity stress